Alcohol and other hypnotics action in your brain Receptors
By the middle of the 10th century, Darwin devices a brain and behavior shape theory: the modern perspective of materialism: The philosophy which upholds matter to be the principal stem of everything and every state including mental states and consciousness which seems kind of right when you think about it. Psychotic patients for example tend to lose it because of some injury, or lesion in their brain and not due to some unrealistic matter or demons.
Considering the materialistic effect of alcohol and other Sedative- Hypnotics…
Materialism: The philosophy which upholds matter to be the principal stem of everything and every state including mental states and consciousness.
Charles Darwin
The effect of sedatives is to calm or moderate nervousness or excitement and hypnotics is to induce sleep;
The most common Sedative- hypnotics are alcohol, barbiturates, and benzodiazepine.
Whereas both alcohol and barbiturates can produce sleep, and anesthesia and come at doses only slightly higher than those that produce sedation, benzodiazepine doses for sleep and anesthesia are quite high than its relieve anxiety dose ;
Sedative- hypnotics act by:
1st, since they are psychoactive drugs, they can cross the blood-brain barrier ( more like a selective gate for accessing the brain ), and act on receptors of the brain.
They influence a receptor of gamma amino butyric acid, the GABA receptors, GABA receptors control a Chloride ions channel that causes an influx of Chloride into the neuron; making it hyperpolarized ( due to increased negativity/ decreased positivity).
This makes it less likely to propagate an Action potential. GABA thus acts by diminishing the neuron cell firing rate; an inhibitory effect ;
The GABA receptor possesses only 1 binding site for GABA; but other 2 sedative-hypnotic sites where alcohol or barbiturate molecules bind, and so producing the same CI-influx effect as that of GABA ;
Benzodiazepine increases the GABA receptor’s affinity to bind to GABA. Its potency is dictated by the availability of GABA molecules.
With their action on GABA an inhibitory neurotransmitter, in the brain, this reduces the overall activity of the brain cells in the frontal lobe and hypothalamus ;
Most Motor actions are controlled by the frontal lobe: therefore the inhibition activity lowers the motor activities This is sedation.
In addition to that, inhibition of hypothalamus activity can lead to sleep induction during the wake cycle – Locally termed hypnosis.
This overall is the sedative-hypnotic cycle of the tequila, whiskey, or hypnotic drug you’ll be taking …
Mmmh.. feel the physiology chemistry behind the alcohol???
BRAINNY ARC 